Actually,
this was discussed a while back.
It's back on page 6 so I won't fault you for not finding it. Here's what I posted with some revisions:
Shizune: I can definitely see her going very far in business, law, or politics. She's already ruthless, cunning, competitive, and intelligent. She has the tools already at her disposal. World domination is possible if she's feeling up to it.
Misha: Shizune's personal aide. If not that, she could be any manner of things because I don't know what her disability is. But really, she's the type to be stuck to Shizune for life.
Hanako: Physically, she is capable of doing anything. It's just her mental and emotional problems that may be the key here. I could see her being successful in a lot of things if her personality were improved. If she were still nervous and all that, hmm, there aren't many jobs that let you avoid human interaction. Perhaps she could work from her home using the internet? I'm afraid that she'll become a reclusive hermit if someone (Hisao) doesn't break her out of her shell.
Emi: I'm not sure what she'd do. Her attitude is pretty good though, so I'm sure she'd do well. She also works well with others. A teacher perhaps?
With Lilly and Rin, they are the most affected by their disabilities.
Lilly: I'm not sure what type of work blind people do. Perhaps she could work for Akira?
Rin: She is most held back as almost all forms of work require arms. She is already good at art, so she may have to go with that. And really, I don't think there's much else she'd rather do with her life.
Hisao: He'd be a salaryman. Or Shizune's lackey/second in command if he goes that way.
Kenji: He'll turn out to be a drunkard, living in his parent's basement, spouting off conspiracy theories.
It's a good thing Shizune is deaf, she is the only one who can stand (not) hearing "Wahaha~!" over and over.