I know what constitutes Asperger's Syndrome - I do, after all, have a milder case of it - and it's quite obvious Rin's an aspie. I'll tell you why. Firstly, there's the severe lack of knowledge of social rules, which is abundant in her case, due to her extremely blunt and deadpan sarcasm, and her rather astounding claims. (NO PHYSICAL PROBLEMS. OBVIOUSLY YOUR JUNK IS MESSED UP. *pokerface* ) Also, there's the fact that she seems to think on entirely different wavelength than other people. Actually, scratch that. She thinks on an entirely different spectrum than other people. Secondly, a common aspect of Asperger's is that they tend to find one interest and be dead-set on pursing this interest, and in Rin's case, this is obviously art. Also, people with Asperger's tend to think of things more logically than emotionally, which explains Rin's nigh-constant poker face.
Personally, I found Rin to be my favorite character perhaps because of this. 4LS did a tremendous job making realistic characters, and Rin is no exception. And that they would put someone like her in a game like this just makes them that much more awesome. Though, I am curious on two things. Firstly, I wonder if she was intentionally modeled after an aspie.
My other curiosity is why can no one else seemingly understand her? I understood her easily, in nearly every conversation, and found her quite enlightening and logical. Heh, maybe it's some kind of aspie psychic-connection or something I have going on with her.

Either that, or Hisao's a darn idiot with social skills that make me look good. And I also have Asperger's. >_<
Anyone else agree or disagree with me? Want to provide further proof or counterexamples? Be my guest, discussion is encouraged.